At the end of the day, the 300 Blackout and the 5.56 NATO both serve their purposes well. The 300 Blackout is the real heavy hitter when it comes to power, suppression, and close-quarters situations.
The 300 Blackout provides users a larger caliber option to 5.56mm in the same platform size. The 300 Blackout has an efficiency advantage compared to the 5.56 when used in shorter barreled firearms.