Mouse neuroblastoma cells (Clone NIE-115) were grown in serum-free (defined) medium, defined medium supplemented with serum, and control medium to determine whether serum-free medium could substitute ...

Muscarinic acetylcholine receptors (mAChRs) are central to the modulation of neurotransmission in the human brain and are emerging as promising targets in the management of neuropsychiatric disorders.

Acetylcholine (AcCho) release from purely cholinergic Torpedo synaptosomes was evoked by K$^{+}$ depolarization in the presence of Ca$^{2+}$. Activation of muscarinic receptors, present in the ...

Asceneuron SA, an emerging leader in the development of innovative small molecules for neurodegenerative diseases, has been awarded a research grant from The Michael J. Fox Foundation for Parkinson’s ...

In the December 2 Nature Chemical Biology, researchers led by Jeffrey Conn at Vanderbilt University, Nashville, Tennessee, report that they have developed a small molecule that not only boosts the ...

Acetylcholine is a chemical messenger, or neurotransmitter, that plays an important role in brain and muscle function. Imbalances in acetylcholine are linked with chronic conditions, such as Alzheimer ...

Using a mouse model of multiple sclerosis (MS), a research team led by UC San Francisco scientists has demonstrated for the first time that regenerating myelin – the fatty insulating sheath ...

In the US, the most common reason why someone needs a liver transplant is alcohol-associated liver disease (ALD)... | Microbiology ...

Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast ...

A recent study posted to the bioRxiv* preprint server assessed the mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and Alpha variants of concern (VOCs) inhibit ...