Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. Bottom: Intestines lacking Daam1 do not form ectopic Paneth cells, a type of secretory cells (left), while ...
As people live longer, the gut quietly accumulates damage that can tip the balance between healthy tissue renewal and chronic ...
Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in the ...