What started as a trickle of data is turning into a rivulet, and may become a stream before long as more and more researchers are testing the idea that β-secretase enzyme activity in cerebrospinal ...

The β-secretase enzyme BACE1 become an instant favorite among researchers interested in developing small-molecule drugs against Alzheimer's disease when it was cloned by researchers at Amgen and even ...

Hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease, scientists report. The new findings show that ...

We first examined whether BACE1 and α-secretase activities could generate two C-terminal fragments (CTFs) of β2 corresponding to the individual cleavage products of β- and α- secretase. Two β2-CTFs ...

In brains with sporadic Alzheimer disease (AD), the critical enzyme beta-secretase1 (BACE1) is known to be elevated. Scientists have now found increased levels of BACE1 in brains with mild cognitive ...

Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of Nature Cancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could ...

Merck ($MRK) has posted a roundup of data generated to date on its BACE1 inhibitor in Alzheimer’s disease tests and trials. The package includes results from a ...

Researchers from the Cleveland Clinic have reversed the development of amyloid plaque in mice with Alzheimer’s disease by gradually depleting their levels of BACE1. The study buoys hope that targeting ...

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer’s disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can ...

The ongoing search for effective treatments for Alzheimer’s disease has focused on aggregates of amyloid-β peptides, which are the hallmark of the disease. However, efforts to inhibit one of the ...