A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation. The ...
The diagnosis of brainstem glioma was long considered a single entity. However, since the advent of magnetic resonance imaging in the late 1980s, neoplasms within this anatomic region are now ...
Like other tumors that arise in midline structures of the brain, most DIPGs are histone H3-mutated tumors that harbor H3K27M mutations. DIPG typically originates in the ventral pons, which is the ...
The study, published in Nature Medicine, identified a small molecule inhibitor that increases histone methylation, compensating for the reduced methylation caused by mutation in the H3F3A gene, ...
Please provide your email address to receive an email when new articles are posted on . Three of four patients who received an investigational chimeric antigen receptor T-cell therapy for diffuse ...
April 9, 2012 (Chicago, Illinois) — A novel peptide vaccine was well tolerated and showed evidence of immunologic and clinical responses in children with gliomas, according to the results of a small ...
Oblato plans to evaluate OKN-007 for diffuse intrinsic pontine glioma in a phase 1/2 trial this year. The Food and Drug Administration (FDA) has fast tracked an investigational therapy for diffuse ...
More recent reports of brainstem tumors include diverse sites such as the cervicomedullary junction, pons, midbrain, or the tectum. Today, these tumors are broadly categorized as either diffuse ...
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