Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

As many as 1 in 4 cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex, which controls access to DNA. A study led by St. Jude Children's Research Hospital recently identified ...

An international team of researchers has assembled one of the largest single-cell genetic atlases ever built, profiling more ...

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at NUS have developed a new method that allows scientists to better understand how DNA is organized and regulated inside ...

Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham ...

New research led by Professor Yogesh Dwivedi at the University of Alabama at Birmingham uncovers how long noncoding RNAs engage chromatin-silencing machinery under glucocorticoid receptor activation, ...

The study outlines a new scenario for understanding how genome regulation and chromatin organization influence the evolution of animal body plans. The conservation of genome regulatory elements over ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, offering fresh insight into how human cells build and maintain chromatin, ...

Deep inside the cells that line and support our arteries, a small chromatin-binding protein is quietly shaping the fate of ...