Novel E3 ligase identified by Kymera’s Whole-Body Atlas is expressed in selected tissues while broadly expressed in cancer cells Novel STAT3 degrader enabled by Pegasus TM platform, and based on ...
In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria ...
Exploring pediatric E3 ligases to enable targeted protein degradation therapies for childhood cancer
This article and associated images are based on a poster originally authored by Ashleigh Hill, Marie-Louise Francis, Viktoria Brachmaier, Egle Vaitone, Rachel Forfar and Sandra Kuemper and presented ...
Ethylene influences plant growth, development, and stress responses via crosstalk with other phytohormones; however, the underlying molecular mechanisms are still unclear. Here, we describe a ...
The publication reports the highly selective, DCAF16 E3 enabled degradation of BRD9 in vivo using Amphista’s proprietary, next generation Targeted Glue™ medicinal chemistry technology Amphista’s ...
Targeted protein degradation (TPD) has transformed cancer drug discovery by enabling removal of harmful proteins using small molecule degraders. PROTACs (Proteolysis Targeting Chimeras) and MGDs ...
Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their ...
An illustration of Lynn McGregor. Credit: Courtesy of Lynn McGregor (McGregor); Novartis (E3 ligase); RCSB PDB (KRAS); Courtesy of Colin Garvie (protein gels) If I weren’t a chemist, I’d be: A ...
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