A new study, led by Professors Mashaghi and Clevers from Leiden University and Hubrecht Institute in the Netherlands, has introduced a novel approach using intestinal organoids to uncover the ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

Organoids are three-dimensional, miniaturized, and simplified versions of organs produced in vitro from stem cells or organ-specific progenitor cells. They recapitulate key structural and functional ...

In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have ...

Organoids have rapidly become revolutionary tools in biomedical research, transforming approaches to drug discovery and disease modeling. These three-dimensional cell culture models have the ...

Attrition in the therapeutic pipeline can typically result from a lack of translational efficacy between the pre-clinical phase and the clinic. Organoids offer much promise in drug screening and ...

What am I looking at? This video shows actin at work in a growing intestinal organoid. The video is depth-coded for color, which means that cooler colors like blue and purple are closer to the viewer ...

Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

Plastics pervade every aspect of the human life, being present in packaging and household goods, agricultural, food and medical products. Their resistance to (bio)degradation has resulted in the ...