Differentiation of multipotent precursor cells into distinct cell lineages is orchestrated by integration of cell-extrinsic cues, such as recognition of soluble or cell-bound ligands, growth factors, ...

Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells. Understanding how these cells work is key to determining how they ...

Yongqiang Feng, PhD, St. Jude Department of Immunology, investigated the role Foxp3 plays in regulatory T cell function, demonstrating that the protein likely acts as a transcription cofactor, ...

Thanks to regulatory T cells (Tregs), the immune system is kept in line via a careful system of checks and balances. Immune response too light? A viral infection spreads throughout the body. Immune ...

Randomized Phase II Study of Bortezomib, Thalidomide, and Dexamethasone With or Without Cyclophosphamide As Induction Therapy in Previously Untreated Multiple Myeloma Diagnostic tissue from 122 ...

Evaluating the Impact of Organizational Changes in Health Care Delivery: Challenges in Study Design FOXP3 expression in tumors was associated with worse overall survival probability and the risk ...

To investigate how FOXP3 dE2 affects tumor immune responses, Li and colleagues examined data from patients with triple-negative breast cancer in The Cancer Genome Atlas (TCGA) and analyzed survival ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...

Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments. The immune system faces a delicate balancing act: it must be ...

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, ...