There's another heavy slate of inter-conference matchups to place Week 6 NFL bets on as there's only one Sunday divisional game. Patriots vs. Saints (+3.5), Colts vs. Cardinals (+8.5), Jaguars vs. Seahawks (-1.

Week 6 of the 2025 NFL season kicked off Thursday with the New York Giants and Philadelphia Eagles being the upset of the week, perhaps before the rest of the games even get played. From there, we have inched towards the day we find ourselves on, which is the Sunday of Week 6.

Factor in the Bills (6.1 percent of entrants), Seahawks (1.3 percent), and more, and only 4,646 entries (out of 18,718) are remaining in the Circa contest that has a grand prize of $15 million. Surely your pool is facing similar results, but we move on to Week 6.

Kellen Moore's team hit on a rare explosive play with an 87-yard bomb from Spencer Rattler to Rasheed Shaheed -- take that long score out and New Orleans averaged just 4.0 yards per play against a questionable Giants defense. New York handed the Saints three pretty unacceptable fumbles as well.

Caleb Williams and the Bears stand in the way of the Commanders trying to take the NFC East lead from the Eagles.

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CBS Sports NFL expert Will Brinson breaks down his top Monday Night Football plays for Week 5 of the NFL season