In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have ...

Attrition in the therapeutic pipeline can often be associated with the lack of translational efficacy from the pre-clinical phase to the clinic. Organoids demonstrate the significant potential to ...

Attrition in the therapeutic pipeline is often linked to the gap in translational efficacy between the pre-clinical phase and clinical outcomes. Organoids offer strong potential for improving disease ...

The trillions of microbes in our gastrointestinal tract, known as the gut microbiome, are crucial to the body; the gut microbiome aids in digestion, nutrient absorption, and influences our health in ...

Intestinal tuft cells divide to make new cells when immunological cues trigger them. Additionally, in contrast to progenitor- and stem cells, tuft cells can survive severe injury such as irradiation ...

A team led by Prof. Dr. Dirk Haller has demonstrated for the first time that defective mitochondria cause injuries in the intestinal epithelium and influence the microbiome. In this microscopic image ...

Scientists optimize organoid culture growth and consistency with validated growth factor panels. Researchers can optimize organoid culture growth and consistency with panels of growth factors that are ...

Organoids are three-dimensional, miniaturized, and simplified versions of organs produced in vitro from stem cells or organ-specific progenitor cells. They recapitulate key structural and functional ...

Cells on the inner surface of the intestine are replaced every few days. But, how does this work? It was always assumed that cells leave the intestinal surface because excess cells are pushed out.