"This model is a valuable tool for characterizing macrophage aging mechanisms and developing innovative strategies with promising therapeutical purpose in limiting inflammaging and ARD.” "This model ...
This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via inflammasome activation, and ...
New research shows lung injury and dysregulated macrophages create an environment that supports tuberculosis growth, offering ...
Antiretroviral therapy has decreased the risk of lymphoma in the HIV-positive patient population, yet the incidence is still approximately 70-times greater than the incidence in the noninfected ...
Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
A tandem signaling process turns ordinary cells into an efficient cleanup crew. Billions of our cells die every day to make way for the growth of new ones. Most of these goners are cleaned up by ...
Tuberculosis (TB) remains a major global health challenge, affecting more than 10 million people annually worldwide, with ...
Metastatic disease-;when cancer spreads from the primary tumor to other parts of the body-;is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to ...
A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC). The research identified enolase 2 (ENO2), a ...
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