If neurons are wires, myelin is the insulation that wraps around them; without it, current loss occurs and the circuit weakens. This is analogous to what happens in demyelinating diseases such as ...

Oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in myelin generation, maintenance, and repair after CNS injuries and in demyelinating diseases. Beyond ...

Scientists have always presumed that the Aβ in plaques comes solely from neurons. Three recent papers challenge that assumption, identifying another, unexpected source—oligodendrocytes. In the ...

How oligodendrocytes use fatty acid metabolism as an energy reserve to maintain axonal function and myelin stability when glucose is scarce, offering insights into neurodegenerative disease mechanisms ...

The results of preclinical studies headed by investigators at the UK Dementia Research Institute at University College London, and colleagues, suggest that non-neuronal brain cells called ...

This important study presents convincing findings on creating an exhaustive library of new enhancer-AAVs targeting astrocytes and oligodendrocytes with high potential for both basic and translational ...

Researchers report that mature oligodendrocytes -- the central nervous system cells critical for brain function -- cling to life following a fatal trauma for much, much longer than scientists knew.

In the brain, it is not only important that nerve cells send signals, but also how quickly they can do so. In order for information to flow smoothly, a kind of biological insulation is necessary. The ...

Researchers at Institute of Science Tokyo have identified laminin-411 and A4G47, a synthetic peptide derived from the E8 domain of laminin-411 protein, as the key factors in the maturation of ...

Multiple sclerosis (MS) degrades the protective insulation around nerve cells, leaving their axons, which carry electrical impulses, exposed like bare wires. This can cause devastating problems with ...

A team of researchers from Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that ...