In the evolutionary history of life, the ability of a cell to separate its inner world from the external environment was an important turning point. The so-called plasma membrane lets cells control ...

The discovery of bifunctional degradation activating compounds (BiDACs) has led to the development of a new class of drugs that promote the clearance of their protein targets. BiDAC-induced ...

Ordered membrane nanodomains colloquially known as “lipid rafts” have many proposed cellular functions. However, pharmacological tools to modulate protein affinity for rafts and to manipulate raft ...

Cellular membrane proteins play important roles in cellular transport, signaling, and cell-to-cell communication. Malfunction in membrane proteins can lead to serious diseases, such as cancer. However ...

Located at the cellular interface, membrane proteins play critical regulatory roles in the signaling between a cell and its interacting environment, making them popular and ideal drug targets.

Membrane proteins are the gateway to cells and are involved in many critical functions. Each membrane protein is unique, and their complexity makes it difficult to fit into a standardized expression ...

Scientists at the VIB–VUB Center for Structural Biology have uncovered a counterintuitive principle that could reshape how membrane proteins are designed from scratch: Sometimes, making a protein less ...

Differences in the surface negative charge between EXOs and PM-EVs manifest as variations in target cell specificity and pharmacokinetics. Therefore, zeta potential measurement can serve as one of the ...