Pyruvate kinase deficiency is a genetic disorder affecting red blood cells that carry oxygen to all cells in the body. People with pyruvate kinase deficiency have chronic hemolytic anemia, meaning ...

HEREDITARY spherocytosis with its associated congenital hemolytic anemia is generally easily recognized and satisfactorily treated with splenectomy. A rarer group of congenital hemolytic anemias, ...

The purpose of this report is to present the findings in a group of 20 patients with pulmonary insufficiency, all but 2 of whom had arterial oxygen tensions below 50 mm. of mercury. The 20 subjects ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

The grass-specific herbicide haloxyfop, ((±)-2-[4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)-phenoxy] propionic acid) has been shown to inhibit lipid synthesis and respiration, to cause the ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

The pyruvate dehydrogenase complex has been purified 76-fold, to a specific activity of 0.6 μmoles per minute per milligram protein, beginning with isolated pea (Pisum sativum L. var Little Marvel) ...

CAMBRIDGE, Mass., May 14, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

Dublin, Oct. 11, 2023 (GLOBE NEWSWIRE) -- The "Global Pyruvic Acid Market 2023-2030" report has been added to ResearchAndMarkets.com's offering. The global pyruvic acid market is anticipated to grow ...

Non-small-cell lung cancer (NSCLC) accounts for up to 85% of all cases of lung cancer, which is the most frequent cause of ...