coli? The answer lies in the difference in gene expression and regulation used. Regulation of transcription in eukaryotes is a result of the combined effects of structural properties (how DNA is ...

In Eukarya, RNA Polymerase II (Pol II) transcription is a highly regulated process, which is responsible for the transcription of all protein encoding genes. While the catalytic core of the Pol II ...

In a study published in Nature Structural and Molecular Biology, scientists from the Department of Medical Biochemistry and ...

Here, we show that deletion of the main transcription factor involved in heat shock gene regulation, heat shock factor 1 (HSF1), affects M-CSF-driven differentiation of mouse bone marrow cells.

Because Mediator interacts with both DNA-binding TFs and the general transcription machinery (including pol II), Mediator acts as a molecular bridge to link these factors and facilitate TF-dependent ...

A new study has unveiled the intricate genetic mechanisms that regulate theanine accumulation in tea plants—a key determinant ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding ... of the genome that are involved in gene regulation and understanding how interactions ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

In a recently published study in Nature Structural and Molecular Biology, scientists from the Department of Medical ...