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Epidermal necrolysis (EN) — which includes Stevens-Johnson syndrome (SJS), toxic EN (TEN), and SJS and TEN overlap — had an incidence of 2.6 cases per million person-years in a French study of adults.

The presence of CKD among patients with SJS or TEN may influence the in-hospital mortality risk associated with analgesic and antipyretic therapies.

Most cases of SJS are probably a cell-mediated hypersensitivity reaction; in some cases monocytes and macrophages are present and auto-antibodies may be pathogenic. SJS is characterized by skin ...