Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene ...

The IDR in TAF2 steers the protein away from active gene promoters, where it participates in transcription initiation, to nuclear speckles — liquid-like compartments that concentrate factors for RNA ...

Premature termination of transcription influences ribosomal RNA output and RNA polymerase I drug sensitivity, revealing a mechanism of resistance to transcription-targeting chemotherapy.

Phase separation in nuclear cell biology represents a conceptual framework for understanding how cells spatially and temporally regulate gene expression.

AI can help protein engineers optimize the transcription enzymes used to make mRNA-based vaccines and therapeutics, say the authors of a new study.

The recognition of mRNA molecules as a transformative class of therapeutic drugs has soared, particularly with the development of COVID 19 mRNA vaccines. The cancer treatment landscape is similarly ...

With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology ...