tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

A 3D illustration of a transfer RNA molecule hovering over a messenger RNA. Transfer RNA acts as an adaptor to convert messenger RNA codons into amino acids during protein synthesis. Credit: ...

Arup Dalal is at the Centre for Cellular, Computational and Integrative Biology, University of Trento, 38123 Trento, Italy. Read the paper: Thioester-mediated RNA aminoacylation and peptidyl-RNA ...

RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste.

Researchers have identified a previously overlooked regulator that determines whether prostate tumors become resistant to therapy.

The Human Genome Project (HGP) ultimately revealed a DNA sequence of 3 billion base pairs known as the human genome, 1 spurring an enormous technological advance in scientific research and the ...

Exploit decades of mechanistic understandings to develop new routes to synthesis of RNA in high yield and purity Specifically, develop approaches targeting mRNA vaccines and therapeutics, CRISPR ...

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and ...

When RNA molecules are synthesized by cells—a critical process in the creation of proteins and other cellular functions—they typically undergo a series of "folding" events that determine their ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and ...