This study provides novel insights into the elongation dynamics of eukaryotic cells and the counteracting mechanisms in place to reduce translation defects during protein synthesis. "Understanding the ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic acid residues in eukaryotic ...

The process of translation by ribosomes, which functions as a factory of protein synthesis, may be impeded by ‘ribosome arrest peptides’ (RAPs). However, underlying mechanisms remain elusive.

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 27 (July 7, 2020), pp. 15609-15619 (11 pages) Ribosome biogenesis is a complex process, and dozens of ...

Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal cellular functions. The DNA blueprint is carefully read, transcribed, and ...

What is it that makes a good story, one that catches your attention and refuses to let go? Does it include a peculiar mystery? A well-motivated conflict which craves resolution? A catchy hook? A ...

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of ...