The I148M variant of PNPLA3 is closely associated with hepatic steatosis. Recent evidence indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated lipolysis, leaving the role ...

The body requires proper management of blood cholesterol and fats, because they serve essential health functions. The three essential blood components which people need to understand are HDL ...

In a small, short duration trial (12 weeks), a new medication called DR10624 reduced triglyceride levels in most patients with severe hypertriglyceridemia by more than 60%, according to a preliminary ...

ATLANTA, GA—Investigational agents that work by inhibiting apolipoprotein C-III (APOC3) are effective at reducing triglyceride levels, two phase IIb studies show. In Bridge-TIMI 73a, treatment with ...

One tart, ruby red juice may have triglyceride-lowering effects.

Transmembrane proteins are crucial vehicles for cellular transport and communication, composing ~20–30% of all proteomes 1 and ~60% of drug targets 2. Understanding mechanisms governing the functional ...

Two new small interfering RNA (siRNA) therapeutics (both Arrowhead Pharmaceuticals), each targeting different genes involved in the regulation of triglyceride-rich lipoproteins, have been shown to be ...

When eating, the body converts extra calories, especially from carbs, sugar, fats, and alcohol, into triglycerides. Triglycerides are a form of fat or lipid, which the body stores away into its fat ...

Older people who have higher levels of triglycerides, a type of fat, may have a lower risk of dementia and a slower cognitive decline over time compared to people who have lower levels, according to ...

Fatty fish, oats, nuts, leafy greens and berries are some of the best heart-healthy options to include in your diet because ...

The higher a person’s triglyceride levels, the more likely they are to experience acute pancreatitis. Very high triglycerides occur when triglyceride levels reach 500 milligrams per deciliter (mg/dl), ...

In patients with severely elevated triglyceride levels who are at risk for acute pancreatitis, the investigational drug plozasiran brought about substantial reductions in triglyceride levels in the ...