Vanqua Bio Highlights Positive Interim Data from its Ongoing Phase 1b Clinical Trial of VQ-101, an Allosteric Activator of GCase for the Treatment of GBA-Parkinson’s and ...

VQ-101 is the first small molecule to demonstrate >70% activation of the lysosomal enzyme glucocerebrosidase (GCase) in GBA-Parkinson’s ...
Brandeis University

Ancient origins of allosteric activation in a Ser-Thr kinase

Moving illustrating allosteric network (blue dots are essential residues for allosteric network) for regulation. The enzyme interconverts between the inactive and active structure.

Key Milestone in ACTIVATE Phase 2 Clinical Trial of BIA 28-6156

Bial, an innovation-driven biopharmaceutical company focused on neurosciences and rare diseases, today announced a significant milestone in its ongoing Phase 2 clinical study, ACTIVATE (clinicaltrials ...
JSTOR Daily

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites.