Heme, an iron–protoporphyrin IX complex, is synthesised through an eight-step pathway beginning and ending in the mitochondrial matrix, with several cytosolic intermediates. Ferrochelatase catalyses ...

GLP-1 drugs have transformed weight loss by suppressing appetite. The other half of the equation — helping the body burn more energy — has received less attention. Focusing on metabolic studies in ...

Scientists at Washington University in St. Louis described for the first time the structure of a bifunctional protein, called CcsBA, that transports heme and attaches it to cytochromes. Credit: Kranz ...

Scientists have long been puzzled by how maturing red blood cells manage to produce all the hemoglobin they need to carry oxygen to tissues, even after shedding the vital structures they need to ...

Higher intake of heme iron, the type found in red meat and other animal products -- as opposed to non-heme iron, found mostly in plant-based foods -- was associated with a higher risk of developing ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

Higher intake of heme iron, the type found in red meat and other animal products - as opposed to non-heme iron, found mostly in plant-based foods - was associated with a higher risk of developing type ...