We have discovered examples of choreoisosteres in the dynamics of cyclohexane. In 1972, Lambert and co-workers examined ring flipping in cyclohexane rings with exocyclic methylenes, geminal dimethyl ...

N=6 in each group. ***: p<0.001. To investigate whether the substituted cyclohexane ring of rapamycin by itself is sufficient to evoke TRPM8 activation, we synthetized and tested ...

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