Two separate stimuli are needed to activate the NLRP3 inflammasome, which is tightly controlled at different levels. Primarily PAMPs and DAMPs, the initial signals activate PRRs or other receptors and ...

In addition, the released mtDNA activates PRRs such as NLRP3 and AIM2 ... pathogen-associated molecular patterns (PAMPs) that gain access to the cytosol during microbial infection and endogenous DAMPs ...

CHOCAHOLICS are left divided after a popular M&S chocolate bar gets a paper packaging revamp. The posh shop is trialling a new method of reducing plastic, but not all shoppers are on board. The ...

There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and ...

Neonatal Onset Multisystem Inflammatory Disease (NOMID) is the most severe subtype of Cryopyrin Associated Periodic Syndromes in which a gain of function mutation in the NLRP3 gene leads to ...

Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China Key Laboratory of Advanced Technologies of Materials Ministry of Education, School ...

Russian President Vladimir Putin expressed Thursday that Russia is open to the idea of a U.S. cease-fire proposal for Ukraine but emphasized that any pause in hostilities would require a host of ...

Immunotherapy. 2013;5(4):365-81.

Correspondence to Dr Pere Ginès, Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; ...