CHOCAHOLICS are left divided after a popular M&S chocolate bar gets a paper packaging revamp. The posh shop is trialling a new method of reducing plastic, but not all shoppers are on board. The ...

Firstly, the mitochondrial outer membrane acts as a platform for the aggregation of MAVS and the formation of the NLRP3 inflammasome ... such as mtDNA and mtRNA, serve as DAMPs that can directly ...

Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China Key Laboratory of Advanced Technologies of Materials Ministry of Education, School ...

Two separate stimuli are needed to activate the NLRP3 inflammasome, which is tightly controlled at different levels. Primarily PAMPs and DAMPs, the initial signals activate PRRs or other receptors and ...

There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and ...

Neonatal Onset Multisystem Inflammatory Disease (NOMID) is the most severe subtype of Cryopyrin Associated Periodic Syndromes in which a gain of function mutation in the NLRP3 gene leads to ...