CHOCAHOLICS are left divided after a popular M&S chocolate bar gets a paper packaging revamp. The posh shop is trialling a new method of reducing plastic, but not all shoppers are on board. The ...

Correspondence to Dr Pere Ginès, Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; ...

Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China Key Laboratory of Advanced Technologies of Materials Ministry of Education, School ...

Two separate stimuli are needed to activate the NLRP3 inflammasome, which is tightly controlled at different levels. Primarily PAMPs and DAMPs, the initial signals activate PRRs or other receptors and ...

There is solid evidence for the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and ...

Neonatal Onset Multisystem Inflammatory Disease (NOMID) is the most severe subtype of Cryopyrin Associated Periodic Syndromes in which a gain of function mutation in the NLRP3 gene leads to ...

Nomination of NLRP3 inhibitor BGE-102 as a development candidate, with initial Ph1 clinical data anticipated by end of 2025 Expansion of discovery efforts based on insights from BioAge’s platform, ...

3): NLRP3 agonists such as DAMPs and PAMPs can trigger the production of ROS, which activates the NLRP3 inflammasome. It is important to note that these models are not mutually exclusive but rather ...