Musunuru and colleagues1 describe in the Journal an innovative approach in which gene editing is applied in the treatment of a very rare disease, the severe urea-cycle disorder carbamoyl-phosphate ...

Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg ...

In previous treat-to-target trials, adjustments to the dose of basal insulin have been made at least weekly, according to ...

Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking ...

One of the more difficult decisions for patients with poorly controlled type 2 diabetes, as well as for their clinicians, is ...

We conducted a phase 2, double-blind, randomized, placebo-controlled, dose-ranging trial that included 11 groups as two cohorts. Participants with obesity (obesity cohort) were randomly assigned ...

Malnutrition in older adults is common, underrecognized, and contributes to poor health and risk of death. Guidelines are available to facilitate prevention and treatment of malnutrition.

A 44-year-old woman presented with cough, dyspnea, and chest pain. On examination, she had tachycardia and hypotension. Evaluation revealed SARS-CoV-2 RNA in a nasopharyngeal swab, as well as eleva ...

Genetic variation in APP, PSEN1, and PSEN2 leads to overproduction and Aβ aggregation and deposition in plaques, and this variation causes Alzheimer’s disease to adhere to a classical mendelian ...

The United States has the world’s highest incarceration rate. 1 At the end of 2020, despite historic declines in the incarcerated population due to Covid-19, 1.7 million people in the United ...