Ubiquitination requires three types of enzyme: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, known as E1s, E2s, and E3s, respectively.

Jun 28, 2025 · Ubiquitin is a small regulatory protein present in virtually all tissues of eukaryotic organisms, from yeast to humans. Discovered in 1975, its name reflects its ubiquitous nature …

Nov 29, 2004 · Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their …

Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction.

Jan 5, 2026 · Ubiquitination, the covalent attachment of ubiquitin to proteins and other cellular substrates, is a dynamic post-translational modification that enables cells to rapidly respond to …

Aug 23, 2018 · Ubiquitin is a small protein that is found in almost all cellular tissues in humans and other eukaryotic organisms, which helps to regulate the processes of other proteins in the …

Feb 28, 2024 · Ubiquitin is a small (8.6 kDa) protein that is found ‘ubiquitously’ in eukaryotic organisms and functions as a regulator of numerous cellular processes. It is a multifaceted …

Ubiquitin is a small protein that plays a critical role in tagging other proteins for degradation via the proteasome, thereby regulating protein levels and maintaining cellular homeostasis.

Ubiquitin is attached to proteins by a cascade of enzymes comprising ubiquitin activating enzyme (E1), ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).

Jun 23, 2025 · Ubiquitin is a small protein that attaches to other proteins within a cell in a process known as ubiquitination. This tagging system is a mechanism for regulating the life of a …